New findings with Topoisomerase II about "loop traps" that compact DNA and revise DNA topology. This increases the ability of the enzyme to act as a stable roadblock, for example to kill tumor cells. The mec… 2/13/2024 This work is founded on early discoveries by TopoGEN scientists, who showed that TOP1cc (topoisomerase I covalent complexes) can be identified, recovered and sequenced. We offer these tools to the scienti… 2/9/2024 Combination anti-cancer therapy: using topoisomerase II drugs with others can create clinical synergy. TopoGEN can help you with this!#topogen #topoisomerases #anticancer #combinati… 1/26/2024 Antibody drug conjugates (ADCs) target killing drugs into tumors and 2 ADC delivering topoisomerase I poisons (Enhertu and Trodelvy) have recently been FDA-approved. This opens significant potential for topoisomerase effica… 1/19/2024 TopoGEN offers powerful and tractable services to quantify the ability of your front line anticancer drug to specifically target endogenous topoisomerase action in cells. Contact us for a quote for services.topog… 1/6/2024 This is a very exciting result about neuronal differentiation and DNA hypo-methylation at enhancers and helps explain why mutations localize at sites of active transcription.TET path enzymes create oxidize… 12/16/2024 "A more vibrant, equitable, and distributed bioeconomy" is a healthy and welcome aspiration nationally, especially for flyover biotechs like TopoGEN and CBx Genomics #bioeconomy #sustainableworkforce #… 9/23/2024 TopoGEN scientists are the experts in efficiently screening compounds that impact topoisomerases and DNA gyrases. We can perform assays in vitro (using our purified enzymes and substrates) or in vivo (as… 7/6/2024 WebAug 5, 2024 · Briefly, 1 μl of gyrase test solution, 4 μl of 5× gyrase “assay” buffer (TopoGEN Inc.), and 250 ng of relaxed pHOT-1 DNA (TopoGEN Inc.) were combined in molecular biology–grade dH 2 O at a final assay volume of 20 μl and incubated at 37°C for 60 min. After incubation, 4 μl of 5× loading “stop” buffer (TopoGEN Inc.) was added ...
Mark Muller - President and CEO - TopoGEN, Inc. LinkedIn
WebTopoGEN 公司是一家专门为拓扑酶研究提供试剂和试剂盒。试剂盒可以有效地分析拓扑异构酶 I ， II 和旋转酶，分析细胞内的拓扑抑制以及描绘拓扑异构酶抑制剂的特性。另外公司还提供 DNa c底物，拓扑抑制剂和抗体等。TopoGENTG2000G-1KIT说明书Purified E. coli DNA Gyrase and Relaxed DNA Kit (plasmid based).Catalog Numbe ... WebJonathan Baell (né Ball) is trained as an Australian medicinal chemist and is currently Executive Director, Early Leads Chemistry at Lyterian Therapeutics in San Francisco. Prior to this, he was a research professor in medicinal chemistry at the Monash Institute of Pharmaceutical Sciences (MIPS), the Director of the Australian Translational Medicinal … goodbye 2020 hello 2021 clipart
Logiciel: TOPOGEN - Cours BTP
Web‣ Le traitement d’un dossier topographique par le logiciel TOPOGEN passe par les étapes suivantes : 1) Acquisition des données. 2) Pose des calcules. 3) Analyse des résultats. 4) Rectification. 5) Impression des résultats et … WebMar 30, 2015 · TopoGen is a small PyGTK application which will make a topographic image overlay for Google Earth using the given coordinate boundaries. Project Samples. Project … WebTopoGEN, Buena Vista, Colorado. 499 likes · 8 were here. TopoGEN is a biotechnology company dedicated to the study of topoisomerase enzymes. goodbye 2002 welcome 2003