WebMar 30, 2024 · FGFR2 fusions, seen in around 13–14% of patients in intracellular cholangiocarcinoma (iCCA), have been identified as an oncogenic events driven in iCCA [43–46]. FGFR2 was commonly elevated in bile duct cancer, especially the intrahepatic cholangiocarcinoma, and thus it is used as a marker and therapeutic target for it [37, 43, … WebApr 1, 2024 · The vast majority of FGFR2 rearrangements found in iCCA are gene fusions, where the 5' (upstream) partner constitutes most of FGFR2, including the promoter region and exons 1 through 17 encoding the extracellular domain, juxtamembrane, and intracellular tyrosine kinase domains, and the 3' (downstream) partner is represented by one of …
FGFR2 gene: MedlinePlus Genetics
WebAug 1, 2016 · FGFR1 and FGFR2 are amplified in many tumor types, yet what determines response to FGFR inhibition in amplified cancers is unknown. In a translational clinical … WebCancer stemness is associated with high malignancy and low differentiation, as well as therapeutic resistance of tumors including pancreatic ductal adenocarcinoma (PDAC). … colt government mk iv
Cogent Biosciences to Showcase Precision Therapy Pipeline
WebFGFR2 (locus: 10q26.13) encodes a receptor for fibroblast growth factor (FGF) signaling. Within the gonad, the isoform FGFR2c acts as the receptor for FGF9 in order to suppress ovarian gene expression ( WNT4 ). Its expression, like FGF9, is regulated by SOX9. FGFR2 mutations have been associated with multiple syndromes including, Crouzon ... WebNov 21, 2024 · Fgfr2 restricts to the AT2 lineage during alveolar differentiation. To identify signaling pathways that might control alveolar cell fate selection, we searched the single-cell transcriptional ... WebThe test is performed using a laboratory-developed FGFR2 (10q26.1) dual-color break-apart strategy probe (BAP). Formalin-fixed, paraffin-embedded tissues are cut at 5 microns and mounted on positively charged glass slides. The selection of tissue and the identification of target areas on the hematoxylin and eosin (H and E)-stained slide is ... colt golf clubs