Cilia and myoblasts review
WebSep 4, 2024 · This review addresses the enigmatic but emerging role of primary cilia in satellite cells in myoblasts and myofibers during myogenesis, as well as the wider tissue … WebSep 4, 2024 · This review addresses the enigmatic but emerging role of primary cilia in satellite cells in myoblasts and myofibers during myogenesis, as well as the wider …
Cilia and myoblasts review
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WebAug 26, 2024 · As microtubule-based structures, primary cilia are typically present on the cells during the G0 or G1-S/G2 phase of the cell cycle and are closely related to the … WebAbstract Cilia are membrane-bounded, centriole-derived projections from the cell surface that contain a microtubule cytoskeleton, the ciliary axoneme, surrounded by a ciliary …
WebApr 4, 2024 · This Review focuses on how cilia establish their unique composition of proteins, lipids and second messengers and how they dynamically regulate their composition to function as signalling ... WebJul 13, 2015 · Here we investigate the role of the primary cilium as a determinant for cell cycle regulation and quiescence. Using a mouse skeletal muscle myoblast culture …
Earlier, we showed that quiescent myoblasts in culture display a distinct transcriptional profile, with altered signaling modules, in particular, enhanced Wnt-TCF signaling [12, 23]. Interestingly, a number of cilium-associated genes showed increased expression in G0. We compiled a putative “ciliome” … See more Myoblasts exit the cell cycle irreversibly during myogenic differentiation. We used immunofluorescence analysis to establish the status of ciliation during entry into terminal arrest. By … See more Cultures triggered for myogenic differentiation yield a heterogeneous population: at 5 days post serum withdrawal, while ~ 80% of nuclei may be found in … See more Induction of quiescence is associated with enhanced clonogenic self-renewal when cells are restored to proliferative conditions [16]. Cells with impaired ciliogenesis showed … See more Recently, primary cilia were shown to be preferentially present on quiescent MuSC and not on activated MuSC, where they play a role in asymmetric cell division during the early regenerative response [20]. To investigate … See more WebFeb 15, 2010 · The primary cilium, which was first so named by Sergei Sorokin (Sorokin, 1968), is a solitary organelle that emanates from the cell surface of most mammalian cell types during growth arrest.Increasing evidence suggests that primary cilia are key coordinators of signaling pathways during development and in tissue homeostasis and, …
WebPrimary cilia have a broad tissue distribution and are present on most cell types in the human body. Until recently, they were considered to be redundant organelles, but progress over the past 5 years has led to an understanding of their role in normal mammalian development. ... The aim of this review is to assess recent insights into the ...
WebJul 1, 2015 · CO25 cells, a mouse myoblast line, contain multiple centrioles and primary cilia. A most unusual feature has been the finding of large numbers of separate … phillip bernardWebMar 29, 2024 · Cilia: The fine hairlike projections from certain cells such as those in the respiratory tract that sweep in unison and help to sweep away fluids and particles. Some … phillip berrie obituaryWebAug 25, 2024 · This review provides a novel perspective on primary cilia in the regulation of lipid raft dynamics. 1. Introduction. Primary cilia are non-motile, 1–10 µm long antenna-like structures observed in a variety of … phillip bernard smithWebJul 3, 2006 · Primary cilia are very small (∼0.2 μm in diameter and ∼5 μm in length) and are usually observed with an electron microscope (), or more routinely with an epifluorescence microscope following immunofluorescent labeling with α-tubulin antibodies ().The primary cilium was once thought to be an evolutionary vestige in vertebrates. phillip bernardoWebCells utilize primary cilia to convert environmental cues, mechanical or chemical, into various cellular signaling essential for development (17–21).During skeletal muscle … phillip bernard fifaWebJan 17, 2024 · Primary cilia are microtubule‑based organelles that are expressed on almost all mammalian cells. It has become apparent that these structures are important signaling hubs that serve crucial roles in Wnt, hedgehog, extracellular signal‑regulated kinase (ERK)/mitogen‑activated protein kinase (MAPK) and Notch signaling pathways. A … phillip berman authorWebApr 4, 2024 · Cilia are microscopic hair-like external cell organelles that are ubiquitously present in nature, also within the human body. They fulfill crucial biological functions: motile cilia provide transportation of fluids and cells, and immotile cilia sense shear stress and concentrations of chemical species. Inspired by nature, scientists have ... phillip berrospe