WebTreatment of acrA strain CL2 with the protonophore carbonyl cyanide m-chlorophenylhydrazone (CCCP) dissipated delta psi, decreased intracellular ATP levels, and resulted in cessation of growth; after a variable period of time (3 to 7 h), growth resumed, ultimately achieving growth rates comparable to those of untreated cells. WebApr 23, 2013 · The stimulating action of penetrating cations on the protonophore-mediated uncoupling is assumed to be useful for medical applications of low (non-toxic) concentrations of protonophores. ... Note that the steady-state level of electric current with C 12 R4 was negligible if no protonophore (CCCP) was added. The current was higher in …
Modes of Communication: Types, Meaning and Examples
WebAbstract. Mitophagy is a selective pathway, which targets and delivers mitochondria to the lysosomes for degradation. Depolarization of mitochondria by the protonophore CCCP … WebSuccessive doses of 1.25 µM CCCP, a protonophore dissipating the inner membrane potential, were then added. It stimulates the mitochondrial respiration until reaching a maximal level. Finally, the addition of 1 mM potassium cyanide (KCN), an inhibitor of respiratory complex IV, evaluated the non-respiratory oxygen consumption, which was ... elite logistix rock hill
Protonophore - Wikipedia
Carbonyl cyanide m-chlorophenyl hydrazone (CCCP; also known as [(3-chlorophenyl)hydrazono]malononitrile) is a chemical inhibitor of oxidative phosphorylation. It is a nitrile, hydrazone and protonophore. In general, CCCP causes the gradual destruction of living cells and death of the organism, although mild doses inducing partial decoupling have been shown to increas… WebCarbonylcyanide-3-chlorophenylhydrazone (CCCP) is a protonophore, which causes uncoupling of proton gradient in the inner mitochondrial membrane, thus inhibiting the … WebCCCP is a protonophore. It disrupts mitochondria membrane potential by transporting protons across the mitochondrial inner membrane, which interferes with the proton … forbes american automobile industry