WebTreatment of Staphylococcus aureus infections is complicated by the development of antibiotic tolerance, a consequence of the ability of S. aureus to enter into a nongrowing, dormant state in which the organisms are referred to as persisters. We report that the clinically approved anthelmintic agent bithionol kills methicillin-resistant S. aureus … WebMar 29, 2024 · Bithionol is an aryl sulphide that is a diphenyl sulphide in which each phenyl group is substituted at position 2 by hydroxy and at positions 3 and 5 by chlorine. A fungicide and anthelmintic, it was used in various topical drug products for the treatment of liver flukes, but withdrawn after being shown to be a potent photosensitizer with the ...
Bisphenol A (BPA) Factsheet National Biomonitoring Program
WebSep 11, 2007 · Bithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the NDA's for bithionol drug products were withdrawn on October 24, 1967 (see the Federal Register of October 31, 1967 (32 FR 15046)). Type Small … WebJan 17, 2024 · New evidence of clinical experience and photopatch tests indicate that bithionol is capable of causing photosensitivity in man when used topically and that in some instances the... campus digital signage software
To Find The Next Antibiotic, Scientists Give Old Drugs A New …
WebMar 29, 2024 · Bithionol is an aryl sulphide that is a diphenyl sulphide in which each phenyl group is substituted at position 2 by hydroxy and at positions 3 and 5 by chlorine. A … Bithionol has been shown to be a potent inhibitor of soluble adenylyl cyclase, an intracellular enzyme important in the catalysis of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP). Soluble adenylyl cyclase is uniquely activated by bicarbonate. The cAMP formed by this enzyme is … See more Bithionol is an antibacterial, anthelmintic, and algaecide. It is used to treat Anoplocephala perfoliata (tapeworms) in horses and Fasciola hepatica (liver flukes). See more LD50 (oral, mouse) is 2100 mg/kg. Bithionol was formerly used in soaps and cosmetics until the U.S. FDA banned it for its See more campus dining college of wooster