Binuclear metalloenzyme
WebOct 1, 1999 · The crystal structure of the complex between the binuclear manganese metalloenzyme arginase and the boronic acid analog of L-arginine, 2(S)-amino-6 … WebMar 15, 2024 · Almost all known potent inhibitors of this monotrimeric binuclear manganese metalloenzyme interact with the pocket entrance and contain a warhead that binds deep into the pocket to interact with the metal coordination network. The common core and R1 groups of the 1,3,4-pyrrolidine hits reported here engages the entrance of the pocket …
Binuclear metalloenzyme
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WebAug 26, 1997 · Arginase is a thermostable (T m = 75 °C) binuclear manganese metalloenzyme which hydrolyzes l-arginine to form l-ornithine and urea.The three-dimensional structures of native metal-depleted arginase, metal-loaded H101N arginase, and metal-depleted H101N arginase have been determined by X-ray crystallographic … WebMay 27, 2010 · Arginase, a key metalloenzyme of the urea cycle that converts L-arginine into L-ornithine and urea, is presently considered a pharmaceutical target for the …
WebFeb 27, 2024 · Arginase, the binuclear metalloenzyme, is a potential target for therapeutic intervention in protozoan infections. Entamoeba histolytica infection causes amebiasis which is the second most common cause of protozoan-related human deaths after malaria. Here, we report the crystal structure of E. histolytica arginase (EhArg) in complex with two ... WebFeb 15, 2012 · The efficiency of the newly designed metalloenzyme was improved using directed evolution techniques, thereby providing feedback for the computational design process.
Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebMetalloenzymes are enzyme proteins containing metal ions (metal cofactors), which are directly bound to the protein or to enzyme-bound nonprotein components (prosthetic …
WebNov 2, 2024 · We extracted the Co-bound domain of Co-SLAC monomer (L87 to L186, including the oxo-bridged cobalt atoms) and compared it with simulated models by paired chain alignment. The experimentally …
WebUrease is a binuclear metalloenzyme extremely selective towards nickel, exhibiting a remarkable rate enhancement of the catalytic reaction. The accepted mechanism proposal for urease describes the coordination of urea to both nickel centers in an O, N bridged mode, enabling the attack of the carbonyl by a bridged hydroxide present first time buyers discountWebMar 9, 2004 · Request PDF Asymmetry in Bridged Binuclear Metalloenzymes: Lessons for the Chemist This microreview describes the structures, properties and mechanisms of … first time buyers dataWebSep 1, 2005 · Phosphotriesterase (PTE) is a binuclear metalloenzyme that catalyzes the hydrolysis of organophosphates, including pesticides and chemical warfare agents, at rates approaching the diffusion ... first time buyers declaration formWebAug 26, 1997 · We conclude that the substitution of a wild-type histidine ligand to Mn2+A compromises metal binding, which in turn compromises protein thermostability and … campground brevard ncWebBinuclear 0x0-bridged non-haem iron complexes (containing the Fe-0-Fe unit) have recently received much attention.' They provide structural models for diiron sites in several proteins involved in oxygen storage (hemerythrin) and oxygen activation (ribonucleotide reductase and methane monooxy- genase) .2 However, very few polynuclear iron ... campground bransonWebJan 19, 2024 · This binuclear zinc–protein complex is able to digest plasmid DNA at rates up to 50 ng/h, and these cleavage rates are affected by changes to amino acid residues near the zinc-binding site. These results indicate that the DFsc scaffold is a good model system to carry out careful structure–function relationship studies to understand key ... campground branson moWebNational Center for Biotechnology Information campground briggsville wi